Since my google alert for “still’s disease” hasn’t been throwing much my way, I thought I’d widen the criteria to include Systemic Juvenile RA to see if that was more productive, since there is a crossover between the two. This is all a learning curve for techno-shy me, but it proved to be a good move as I think this article is pretty interesting:
Macrophage Activation Syndrome is a complication of Still’s Disease – something I never knew until reading this.
IL-18 is expressed in activated macrophages, so it makes sense that monitoring levels is useful. However, it states that it is also useful in monitoring the activity of disease itself and I wonder if it could be the basis of an IL receptor like Anakinra or Tocilizumab in the future. (I’m not a scientist so these are just my idle ponderings).
Lastly, I noticed that the patient was treated with Cyclosporin – a drug that gave me relief for many years but that doesn’t seem to be prescribed very often; I wonder why?
Maybe we’ll see more on the article front from now on…